Primary huge histiocytic sarcoma of the stomach: a case report and systematic review

Histiocytic sarcoma (HS) is a very rare lympho hematopoietic malignant neoplasm. Up to date, only a small number of gastric histiocytic sarcoma has been reported. In the present study, we reported a case of a primary huge histiocytic sarcoma of stomach in a youth man of 20 years old. Imaging examinations showed a large mass in the lesser curvature and antrum of the stomach. Then a distal subtotal gastrectomy was perfumed and a huge tumor of 15 cm × 13 cm was resected and diagnosed as histiocytic sarcoma by histopathologic examination and immunohistochemical analyses. To investigate the clinical characteristics of the rare histiocytic sarcoma of stomach, we also performed a systematic review by searching relevant literature up to Aug 2015 in the databases of PubMed, ISI web of science, CNKI, and Wangfang. Finally, a total of 14 cases including ours were included. The average age of these patients was 57.9 years. They usually presented a long time abdominal pain before diagnosis. Only rare patients survived for a relative long time and the postoperative chemotherapy might be favorable.